Homo sapiens · TP53 Y163C
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Characterise variant
Build & judge structure
Interpret evidence
Design intervention
Nine agents read the same loaded structure. Anything not actually computed is marked pending or not evaluated — no result is invented.
Modelled residue at 163
Data pendingDATA PENDING
Bulky aromatic phenol lost; small thiol gained — volume loss plus a new reactive -SH
Hotspot context
Data pendingDATA PENDING
Thermodynamic ΔΔG
Not evaluatedNOT YET EVALUATED — no folding free-energy calculation run
Open questions
- · How much of the phenotype is cavity creation versus the free cysteine itself?
- · Is Cys163 solvent-exposed enough for covalent chemistry in the folded state?
Next experiments
- → Run a ΔΔG predictor on the Y163C substitution against the 8QWL crystal reference
- → Compute solvent-accessible surface area for Cys163 in both models